glibenclamide?

i want to know the literature review of glibenclamide .Is it is useful only to the patients who are unable to take the insulin ?
Answer:
It is called glyburide in the US. It is used as an adjunct to diet to lower the blood glucose in patients with non-insulin-dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.Glibenclamide (INN), also known as glyburide (USAN), is an anti-diabetic drug in a class of medications known as sulfonylureas, used in the treatment of type II diabetes. The drug works by inhibiting ATP-sensitive potassium channels in pancreatic beta cells. This inhibition causes cell membrane depolarization, opening of voltage-dependent calcium channels, thus triggering an increase in intracellular calcium into the beta cell which stimulates insulin release. It is sold in doses of 1.25mg, 2.5mg and 5mg, under the trade names Diabeta庐, Glynase庐 and Micronase庐 in the United States and Daonil庐, Semi-Daonil庐 and Euglucon庐 in the United Kingdom.It is also sold in combination with metformin under the trade name Glucovance庐.My question to you is why would somebody be unable to use insulin? Insulin is a naturally occuring hormone produced by the pancreas. With the newer human insulins available today, no one should be unable to use insulin.Hope this helps.Rick the Pharmacist

---

Here is one source of INFO...http://www.sopharma.com/glibenclamide.ph...
but if you want more..just put in your search engine "glibenclamide ", and you are gonna have more sites with info.Good luck.

---